Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye

Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye

Abstract Background Age-related macular degeneration (AMD) is a devastating eye disease causing irreversible vision loss in the elderly. Retinal pigment epithelium (RPE), the primary cell type that is afflicted in AMD, undergoes programmed cell death in the late stages of the disease. However, the e...

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Bibliographic Details
Main Authors: Jiangyuan Gao, Jing Z. Cui, Eleanor To, Sijia Cao, Joanne A. Matsubara
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Journal of Neuroinflammation
Subjects:
Age-related macular degeneration
Retinal pigment epithelium
NLRP3 inflammasome
Cell death
Amyloid beta
Online Access:http://link.springer.com/article/10.1186/s12974-018-1062-3

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http://link.springer.com/article/10.1186/s12974-018-1062-3

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