Randomized Phase II Trial of Triapine-Cisplatin-Radiotherapy for Locally Advanced Stage Uterine Cervix or Vaginal Cancers

Randomized Phase II Trial of Triapine-Cisplatin-Radiotherapy for Locally Advanced Stage Uterine Cervix or Vaginal Cancers

Uterine cervix or vaginal cancers have inherent overactivity of ribonucleotide reductase (RNR), making these cancers rational targets for therapy based on interruption of cisplatin-radiotherapy-induced DNA damage repair. We conducted a pilot, open-label randomized phase II trial to evaluate the effi...

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Bibliographic Details
Main Authors: Charles A. Kunos, Stephen J. Andrews, Kathleen N. Moore, Hye Sook Chon, S. Percy Ivy
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
triapine
cisplatin
radiotherapy
cervical cancer
uterine cervix cancer
randomized phase II
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01067/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01067/full

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