2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function

2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function

Abstract Background High mobility group box 1 protein (HMGB1) is an alarmin following its release by immune cells upon cellular activation or stress. High levels of extracellular HMGB1 play a critical role in impairing the clearance of invading pulmonary pathogens and dying neutrophils in the injure...

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Bibliographic Details
Main Authors: Mao Wang, Alex G. Gauthier, Thomas P. Kennedy, Haichao Wang, Uday Kiran Velagapudi, Tanaji T. Talele, Mosi Lin, Jiaqi Wu, LeeAnne Daley, Xiaojing Yang, Vivek Patel, Sung Soo Mun, Charles R. Ashby, Lin L. Mantell
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Medicine
Subjects:
Cystic fibrosis
Pulmonary infection
HMGB1
Macrophage functions
Phagocytosis
ODSH
Online Access:https://doi.org/10.1186/s10020-021-00334-y

Internet

https://doi.org/10.1186/s10020-021-00334-y

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