Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth.

Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth.

The INK4A locus codes for two independent tumor suppressors, p14ARF and p16/CDKN2A, and is frequently mutated in many cancers. Here we report a novel deletion/substitution from CC to T in the shared exon 2 of p14ARF/p16 in a melanoma cell line. This mutation aligns the reading frames of p14ARF and p...

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Bibliographic Details
Main Authors: Richard T Williams, Lisa M Barnhill, Huan-Hsien Kuo, Wen-Der Lin, Ayse Batova, Alice L Yu, Mitchell B Diccianni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3914946?pdf=render

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http://europepmc.org/articles/PMC3914946?pdf=render

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