Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.

Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.

BACKGROUND AND AIMS:The proportion of serum carnosinase (CN-1) recognized by RYSK173 monoclonal antibody negatively correlates with CN-1 activity. We thus hypothesized that the epitope recognized by RYSK173 is accessible only in a catalytically incompetent conformation of the zinc dependent enzyme a...

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Bibliographic Details
Main Authors: Shiqi Zhang, Holger A Lindner, Sarah Kabtni, Jaap van den Born, Stephan Bakker, Gerjan Navis, Bernard Krämer, Benito Yard, Sibylle Hauske
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4723063?pdf=render

Internet

http://europepmc.org/articles/PMC4723063?pdf=render

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