Late cardiac sodium current can be assessed using automated patch-clamp [v1; ref status: indexed, http://f1000r.es/4kj]
The cardiac late Na+ current is generated by a small fraction of voltage-dependent Na+ channels that undergo a conformational change to a burst-gating mode, with repeated openings and closures during the action potential (AP) plateau. Its magnitude can be augmented by inactivation-defective mutation...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2014-10-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | http://f1000research.com/articles/3-245/v1 |