Decrease of Cardiac Parkin Protein in Obese Mice

Mitophagy plays a major role in heart physiology. Impairment of Parkin-dependent mitophagy in heart is known to be deleterious. Obesity is a known cardiovascular risk factor. Impaired autophagy has been reported in models of obesity or hyperlipidemia/hypercholesterolemia; however less is known regar...

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Bibliographic Details
Main Authors: Amandine Thomas, Stefanie Marek-Iannucci, Kyle C. Tucker, Allen M. Andres, Roberta A. Gottlieb
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2019.00191/full