Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

<p>Abstract</p> <p>Background</p> <p>The presence of somatic mitochondrial DNA (mtDNA) mutations in cancer cells has been interpreted in controversial ways, ranging from random neutral accumulation of mutations, to positive selection for high pathogenicity, or conversel...

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Bibliographic Details
Main Authors: Pereira Luísa, Soares Pedro, Máximo Valdemar, Samuels David C
Format: Article
Language:English
Published: BMC 2012-02-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/12/53

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http://www.biomedcentral.com/1471-2407/12/53

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