Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome.

Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome.

Neuroblastoma is characterized by a relative paucity of recurrent somatic mutations at diagnosis. However, recent studies have shown that the mutational burden increases at relapse, likely as a result of clonal evolution of mutation-carrying cells during primary treatment. To inform the development...

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Main Authors: Olivia M Padovan-Merhar, Pichai Raman, Irina Ostrovnaya, Karthik Kalletla, Kaitlyn R Rubnitz, Eric M Sanford, Siraj M Ali, Vincent A Miller, Yael P Mossé, Meaghan P Granger, Brian Weiss, John M Maris, Shakeel Modak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5172533?pdf=render

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http://europepmc.org/articles/PMC5172533?pdf=render

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