Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors.

Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors.

Proteasome inhibitors (PIs) potently induce apoptosis in a variety of tumor cells, but the underlying mechanisms are not fully elucidated. Comparing PI-induced apoptosis susceptibilities of various mouse embryonic fibroblast (MEF) lines differing in their c-jun N-terminal kinase (JNK) 1 and 2 status...

Full description

Bibliographic Details
Main Authors: Sabine Pietkiewicz, Dennis Sohn, Roland P Piekorz, Susanne Grether-Beck, Wilfried Budach, Kanaga Sabapathy, Reiner U Jänicke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3623862?pdf=render

Internet

http://europepmc.org/articles/PMC3623862?pdf=render

Similar Items