Structural characteristics and membrane interactions of tandem α-synuclein oligomers

Abstract Pre-fibrillar oligomers of α-synuclein are thought to be pathogenic molecules leading to neurotoxicity associated with Parkinson’s disease and other neurodegenerative disorders. However, small oligomers are difficult to isolate for study. To gain better insight into the properties of small...

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Bibliographic Details
Main Authors: Chunhua Dong, Marion Hoffmann, Xi Li, Meijing Wang, Craig R. Garen, Nils O. Petersen, Michael T. Woodside
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-25133-0