Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning

Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning

The robust axonal growth and regenerative capacities of young neurons decrease substantially with age. This developmental downregulation of axonal growth may facilitate axonal pruning and neural circuit formation but limits functional recovery following nerve damage. While external factors influenci...

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Bibliographic Details
Main Authors: Kanako Kumamoto, Tokuichi Iguchi, Ryuichi Ishida, Takuya Uemura, Makoto Sato, Shinji Hirotsune
Format: Article
Language:English
Published: The Company of Biologists 2017-07-01
Series:Biology Open
Subjects:
LIS1
Axonal transport
Axonal extension
Pruning
Nerve degeneration
Nerve regeneration
Online Access:http://bio.biologists.org/content/6/7/1041

Internet

http://bio.biologists.org/content/6/7/1041

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