The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is essential for Treg-mediate immune balance, with Treg-...

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Bibliographic Details
Main Authors: Bing Liu, Oscar C. Salgado, Sangya Singh, Keli L. Hippen, Jason C. Maynard, Alma L. Burlingame, Lauren E. Ball, Bruce R. Blazar, Michael A. Farrar, Kristin A. Hogquist, Hai-Bin Ruan
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08300-3

Internet

https://doi.org/10.1038/s41467-019-08300-3

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