The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is essential for Treg-mediate immune balance, with Treg-...
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Bibliographic Details
Main Authors: |
Bing Liu,
Oscar C. Salgado,
Sangya Singh,
Keli L. Hippen,
Jason C. Maynard,
Alma L. Burlingame,
Lauren E. Ball,
Bruce R. Blazar,
Michael A. Farrar,
Kristin A. Hogquist,
Hai-Bin Ruan |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2019-01-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-019-08300-3
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