A meta-analysis of threats to valid clinical inference in preclinical research of sunitinib

A meta-analysis of threats to valid clinical inference in preclinical research of sunitinib

Poor study methodology leads to biased measurement of treatment effects in preclinical research. We used available sunitinib preclinical studies to evaluate relationships between study design and experimental tumor volume effect sizes. We identified published animal efficacy experiments where suniti...

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Bibliographic Details
Main Authors: Valerie C Henderson, Nadine Demko, Amanda Hakala, Nathalie MacKinnon, Carole A Federico, Dean Fergusson, Jonathan Kimmelman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
systematic review
meta-analysis
cancer
preclinical
Online Access:https://elifesciences.org/articles/08351

Internet

https://elifesciences.org/articles/08351

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