A CRM1 Inhibitor Alleviates Cardiac Hypertrophy and Increases the Nuclear Distribution of NT-PGC-1α in NRVMs

A CRM1 Inhibitor Alleviates Cardiac Hypertrophy and Increases the Nuclear Distribution of NT-PGC-1α in NRVMs

Chromosomal maintenance 1 (CRM1) inhibitors display antihypertrophic effects and control protein trafficking between the nucleus and the cytoplasm. PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1alpha) is a type of transcriptional coactivator that predominantly resides in the...

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Bibliographic Details
Main Authors: Zuheng Liu, Haiping Tian, Jinghai Hua, Wanqiang Cai, Yujia Bai, Qiong Zhan, Wenyan Lai, Qingchun Zeng, Hao Ren, Dingli Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
CRM1
NT-PGC-1α
myocardial infarction
antihypertrophy
nuclear distribution
cardiac function
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00465/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00465/full

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