Agrin Influences Botulinum Neurotoxin A-Induced Nerve Sprouting via miR-144-agrin-MuSK Signaling

Agrin Influences Botulinum Neurotoxin A-Induced Nerve Sprouting via miR-144-agrin-MuSK Signaling

Botulinum neurotoxin (BoNT) has become a powerful therapeutic tool, and is extensively used in aesthetic medicine and in the treatment of neurological disorders. However, its duration of effect is limited, mainly owing to nerve sprouting. Inhibition of nerve sprouting to prolong the effective durati...

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Bibliographic Details
Main Authors: Lin Ma, Lizhen Pan, Wuchao Liu, Ying Liu, Xuerui Xiang, Yougui Pan, Xiaolong Zhang, Lingjing Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
botulinum neurotoxin
nerve sprouting
agrin
muscle-specific receptor tyrosine kinase
microRNA
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00015/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00015/full

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