HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
The HIV-1 accessory protein viral protein R (Vpr) causes G2 arrest and apoptosis in infected cells. We previously identified the DNA damage-signaling protein ATR as the cellular factor that mediates Vpr-induced G2 arrest and apoptosis. Here, we examine the mechanism of induction of apoptosis by Vpr...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-12-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC1665652?pdf=render |