Extremely Thermostabilizing Core Mutations in Coiled-Coil Mimetic Proteins of HIV-1 gp41 Produce Diverse Effects on Target Binding but Do Not Affect Their Inhibitory Activity

Extremely Thermostabilizing Core Mutations in Coiled-Coil Mimetic Proteins of HIV-1 gp41 Produce Diverse Effects on Target Binding but Do Not Affect Their Inhibitory Activity

A promising strategy to neutralize HIV-1 is to target the gp41 spike subunit to block membrane fusion with the cell. We previously designed a series of single-chain proteins (named covNHR) that mimic the trimeric coiled-coil structure of the gp41 N-terminal heptad repeat (NHR) region and potently in...

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Bibliographic Details
Main Authors: Mario Cano-Muñoz, Samuele Cesaro, Bertrand Morel, Julie Lucas, Christiane Moog, Francisco Conejero-Lara
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomolecules
Subjects:
HIV
AIDS
envelope glycoprotein
stability
fusion inhibitors
calorimetry
Online Access:https://www.mdpi.com/2218-273X/11/4/566

Internet

https://www.mdpi.com/2218-273X/11/4/566

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