Complex structure of engineered modular domains defining molecular interaction between ICAM-1 and integrin LFA-1.

Complex structure of engineered modular domains defining molecular interaction between ICAM-1 and integrin LFA-1.

Intermolecular contacts between integrin LFA-1 (α(L)β(2)) and ICAM-1 derive solely from the integrin α(L) I domain and the first domain (D1) of ICAM-1. This study presents a crystal structure of the engineered complex of the α(L) I domain and ICAM-1 D1. Previously, we engineered the I domain for hig...

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Bibliographic Details
Main Authors: Sungkwon Kang, Chae Un Kim, Xiaoling Gu, Roisin M Owens, Sarah J van Rijn, Vanissra Boonyaleepun, Yuxin Mao, Timothy A Springer, Moonsoo M Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3431320?pdf=render

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http://europepmc.org/articles/PMC3431320?pdf=render

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