Evaluation of the Toxicity of 5-Aryl-2-Aminoimidazole-Based Biofilm Inhibitors against Eukaryotic Cell Lines, Bone Cells and the Nematode Caenorhabditis elegans

Evaluation of the Toxicity of 5-Aryl-2-Aminoimidazole-Based Biofilm Inhibitors against Eukaryotic Cell Lines, Bone Cells and the Nematode Caenorhabditis elegans

Previously, we have synthesized several series of compounds based on the 5-aryl-2-aminoimidazole scaffold, which showed a preventive activity against microbial biofilms. We here studied the cytotoxicity of the most active compounds of each series. First, the cytostatic activity was investigated aga...

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Bibliographic Details
Main Authors: Hans Steenackers, Akanksha Dubey, Stijn Robijns, Denis Ermolat'ev, Nicolas Delattin, Barbara Dovgan, Lenart Girandon, Mirjam Fröhlich, Katrijn De Brucker, Bruno P. A. Cammue, Karin Thevissen, Jan Balzarini, Erik V. Van der Eycken, Jozef Vanderleyden
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:Molecules
Subjects:
5-aryl-2-aminoimidazole
biofilm inhibitor
toxicity
tumor cell lines
bone cells
Caenorhabditis elegans
Online Access:http://www.mdpi.com/1420-3049/19/10/16707

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http://www.mdpi.com/1420-3049/19/10/16707

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