Calenduloside E Analogues Protecting H9c2 Cardiomyocytes Against H2O2-Induced Apoptosis: Design, Synthesis and Biological Evaluation

Calenduloside E Analogues Protecting H9c2 Cardiomyocytes Against H2O2-Induced Apoptosis: Design, Synthesis and Biological Evaluation

Modulation of apoptosis is therapeutically effective in cardiomyocytes damage. Calenduloside E (CE), a naturally occurring triterpenoid saponin, is a potent anti-apoptotic agent. However, little is known about its synthetic analogues on the protective effects in apoptosis of cardiomyocytes. The pres...

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Bibliographic Details
Main Authors: Yu Tian, Yu-Yang Du, Hai Shang, Min Wang, Zhong-Hao Sun, Bao-Qi Wang, Di Deng, Shan Wang, Xu-Dong Xu, Gui-Bo Sun, Xiao-Bo Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
Calenduloside E (CE) analogues
triterpenoid saponin
cardiomyocytes
apoptosis
ROS
anti-apoptotic mechanism
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00862/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00862/full

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