Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis

Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis

Abstract Background Autologous tolerogenic dendritic cells (tolDC) are a promising therapeutic strategy for inflammatory arthritis (IA) as they can regulate autoantigen-specific T cell responses. Here, we investigated two outstanding priorities for clinical development: (i) the suitability of using...

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Bibliographic Details
Main Authors: Rachel Spiering, Manon A. A. Jansen, Matthew J. Wood, Anshorulloh A. Fath, Oliver Eltherington, Amy E. Anderson, Arthur G. Pratt, Willem van Eden, John D. Isaacs, Femke Broere, Catharien M. U. Hilkens
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Translational Medicine
Subjects:
Human
Inflammatory arthritis
Heat shock proteins
Tolerogenic dendritic cells
Tr1
Online Access:http://link.springer.com/article/10.1186/s12967-019-2128-4

Internet

http://link.springer.com/article/10.1186/s12967-019-2128-4

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