Obesity Increases Mitogen-Activated Protein Kinase Phosphatase-3 Levels in the Hypothalamus of Mice

Obesity Increases Mitogen-Activated Protein Kinase Phosphatase-3 Levels in the Hypothalamus of Mice

Mitogen-activated Protein Kinase Phosphatase 3 (MKP-3) has been involved in the negative regulation of insulin signaling. The absence of MKP-3 is also associated with reduced adiposity, increased energy expenditure and improved insulin sensitivity. The MKP-3 is known as the main Erk1/2 phosphatase a...

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Bibliographic Details
Main Authors: Bárbara de A. Rodrigues, Vitor R. Muñoz, Gabriel K. Kuga, Rafael C. Gaspar, Susana C. B. R. Nakandakari, Barbara M. Crisol, José D. Botezelli, Luciana S. S. Pauli, Adelino S. R. da Silva, Leandro P. de Moura, Dennys E. Cintra, Eduardo R. Ropelle, José R. Pauli
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
MKP-3
insulin
hypothalamus
obesity
food intake
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00313/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00313/full

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