Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation

Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation

<p>Abstract</p> <p>Background</p> <p>Exposure to particulate matter (PM) is a significant risk factor for increased cardiopulmonary morbidity and mortality. The mechanism of PM-mediated pathophysiology remains unknown. However, PM is proinflammatory to the endothelium a...

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Bibliographic Details
Main Authors: Wang Ting, Wang Lichun, Moreno-Vinasco Liliana, Lang Gabriel D, Siegler Jessica H, Mathew Biji, Usatyuk Peter V, Samet Jonathan M, Geyh Alison S, Breysse Patrick N, Natarajan Viswanathan, Garcia Joe G N
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Particle and Fibre Toxicology
Subjects:
Calpain
Endothelial permeability
Particulate matter
ROS
TRPM2
Online Access:http://www.particleandfibretoxicology.com/content/9/1/35

Internet

http://www.particleandfibretoxicology.com/content/9/1/35

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