Localized Delivery of Cl-Amidine From Electrospun Polydioxanone Templates to Regulate Acute Neutrophil NETosis: A Preliminary Evaluation of the PAD4 Inhibitor for Tissue Engineering

Localized Delivery of Cl-Amidine From Electrospun Polydioxanone Templates to Regulate Acute Neutrophil NETosis: A Preliminary Evaluation of the PAD4 Inhibitor for Tissue Engineering

Upon interaction, neutrophils can potentially release neutrophil extracellular traps (NETs) on the surface of an implanted electrospun template, which may be a significant preconditioning event for implantable biomaterials of yet unknown consequences. In this study, we investigated the potential of...

Full description

Bibliographic Details
Main Authors: Allison E. Fetz, Indira Neeli, Karyl K. Buddington, Robert W. Read, Matthew P. Smeltzer, Marko Z. Radic, Gary L. Bowlin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
electrospinning
tissue regeneration
biomaterials
neutrophils
neutrophil extracellular traps
NETosis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00289/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00289/full

Similar Items