Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo

Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo

Yeast DEAD-box helicase Ded1 stimulates translation initiation, particularly of mRNAs with structured 5'UTRs. Interactions of the Ded1 N-terminal domain (NTD) with eIF4A, and Ded1-CTD with eIF4G, subunits of eIF4F, enhance Ded1 unwinding activity and stimulation of preinitiation complex (PIC) a...

Full description

Bibliographic Details
Main Authors: Suna Gulay, Neha Gupta, Jon R Lorsch, Alan G Hinnebusch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
Ded1/Ddx3
RNA helicase
eIF4E
eIF4A
eIF4G
translation initiation
Online Access:https://elifesciences.org/articles/58243

Internet

https://elifesciences.org/articles/58243

Similar Items