Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer's disease

Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer's disease

Adult hippocampal neurogenesis is strongly impaired in Alzheimer's disease (AD). In several mouse models of AD, it was shown that adult-born neurons exhibit reduced survival and altered synaptic integration due to a severe lack of dendritic spines. In the present work, using the APPxPS1 mouse m...

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Bibliographic Details
Main Authors: Kevin Richetin, Manon Moulis, Aurélie Millet, Macarena S. Arràzola, Trinovita Andraini, Jennifer Hua, Noélie Davezac, Laurent Roybon, Pascale Belenguer, Marie-Christine Miquel, Claire Rampon
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Neurobiology of Disease
Subjects:
Adult neurogenesis
Neurod1
Mitochondria
Dentate gyrus
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117300517

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http://www.sciencedirect.com/science/article/pii/S0969996117300517

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