Ubiquitination events that regulate recombination of immunoglobulin loci gene segments

Ubiquitination events that regulate recombination of immunoglobulin loci gene segments

Programmed DNA mutagenesis events in the immunoglobulin (Ig) loci of developing B cells utilize the common and conserved mechanism of protein ubiquitination for subsequent proteasomal degradation to generate the required antigen-receptor diversity. Recombinase proteins RAG1 and RAG2, necessary for V...

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Bibliographic Details
Main Authors: Jaime eChao, Gerson eRothschild, Uttiya eBasu
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Immunology
Subjects:
DNA Repair
Ubiquitination
AID
Class switch recombination
somatic hypermutation
RAG proteins
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00100/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00100/full

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