MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage.

MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage.

Inflammatory β-cell failure contributes to type 1 and type 2 diabetes pathogenesis. Pro-inflammatory cytokines cause β-cell dysfunction and apoptosis, and lysine deacetylase inhibitors (KDACi) prevent β-cell failure in vitro and in vivo, in part by reducing NF-κB transcriptional activity. We investi...

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Bibliographic Details
Main Authors: Anna Lindeløv Vestergaard, Claus Heiner Bang-Berthelsen, Tina Fløyel, Jonathan Lucien Stahl, Lisa Christen, Farzaneh Taheri Sotudeh, Peter de Hemmer Horskjær, Klaus Stensgaard Frederiksen, Frida Greek Kofod, Christine Bruun, Lukas Adrian Berchtold, Joachim Størling, Romano Regazzi, Simranjeet Kaur, Flemming Pociot, Thomas Mandrup-Poulsen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6160007?pdf=render

Internet

http://europepmc.org/articles/PMC6160007?pdf=render

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