Automated size selection for short cell-free DNA fragments enriches for circulating tumor DNA and improves error correction during next generation sequencing.

Automated size selection for short cell-free DNA fragments enriches for circulating tumor DNA and improves error correction during next generation sequencing.

Circulating tumor-derived cell-free DNA (ctDNA) enables non-invasive diagnosis, monitoring, and treatment susceptibility testing in human cancers. However, accurate detection of variant alleles, particularly during untargeted searches, remains a principal obstacle to widespread application of cell-f...

Full description

Bibliographic Details
Main Authors: Sabine Hellwig, David A Nix, Keith M Gligorich, John M O'Shea, Alun Thomas, Carrie L Fuertes, Preetida J Bhetariya, Gabor T Marth, Mary P Bronner, Hunter R Underhill
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6059400?pdf=render

Internet

http://europepmc.org/articles/PMC6059400?pdf=render

Similar Items