Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

Newly-formed synaptic vesicles (SVs) are rapidly acidified by vacuolar adenosine triphosphatases (vATPases), generating a proton electrochemical gradient that drives neurotransmitter loading. Clathrin-mediated endocytosis is needed for the formation of new SVs, yet it is unclear when endocytosed ves...

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Bibliographic Details
Main Authors: Zohreh Farsi, Sindhuja Gowrisankaran, Matija Krunic, Burkhard Rammner, Andrew Woehler, Eileen M Lafer, Carsten Mim, Reinhard Jahn, Ira Milosevic
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
synaptic vesicle
proton pump
clathrin coat
endocytosis
vATPase
acidification
Online Access:https://elifesciences.org/articles/32569

Internet

https://elifesciences.org/articles/32569

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