Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity
Newly-formed synaptic vesicles (SVs) are rapidly acidified by vacuolar adenosine triphosphatases (vATPases), generating a proton electrochemical gradient that drives neurotransmitter loading. Clathrin-mediated endocytosis is needed for the formation of new SVs, yet it is unclear when endocytosed ves...
Main Authors: | Zohreh Farsi, Sindhuja Gowrisankaran, Matija Krunic, Burkhard Rammner, Andrew Woehler, Eileen M Lafer, Carsten Mim, Reinhard Jahn, Ira Milosevic |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-04-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/32569 |
Similar Items
-
Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling
by: Ira Milosevic
Published: (2018-02-01) -
An unmet actin requirement explains the mitotic inhibition of clathrin-mediated endocytosis
by: Satdip Kaur, et al.
Published: (2014-02-01) -
The Role of Molecular Chaperones in Clathrin Mediated Vesicular Trafficking
by: Rui eSousa, et al.
Published: (2015-05-01) -
Investigating the Heterogeneities of Clathrin Dynamics
by: Willy, Nathan
Published: (2019) -
Clathrin-independent pathways do not contribute significantly to endocytic flux
by: Vassilis Bitsikas, et al.
Published: (2014-09-01)