Regulation of Mycobacterium-specific mononuclear cell responses by 25-hydroxyvitamin D3.

The active vitamin D metabolite, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), has been shown to be an important regulator of innate and adaptive immune function. In addition, synthesis of 1,25(OH)(2)D(3) from 25-hydroxyvitamin D(3) (25(OH)D(3)) by the enzyme 1α-hydroxylase in monocytes upon activat...

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Bibliographic Details
Main Authors: Corwin D Nelson, Brian J Nonnecke, Timothy A Reinhardt, W Ray Waters, Donald C Beitz, John D Lippolis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3125300?pdf=render