An Efficient New Route to Dihydropyranobenzimidazole Inhibitors of HCV Replication

A class of dihydropyranobenzimidazole inhibitors was recently discovered that acts against the hepatitis C virus (HCV) in a new way, binding to the IRES-IIa subdomain of the highly conserved 5' untranslated region of the viral RNA and thus preventing the ribosome from initiating translation. Ho...

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Bibliographic Details
Main Authors: B. Mikael Bergdahl, Thomas Hermann, Emily Satkiewicz, Matthew A. Parker
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Molecules
Subjects:
HCV
RNA
Online Access:http://www.mdpi.com/1420-3049/16/1/281/