Tuning of Alternative Splicing - Switch From Proto-Oncogene to Tumor Suppressor

<p>STAT5B, a specific member of the STAT family, is intimately associated with prostate tumor progression. While the full form of STAT5B is thought to promote tumor progression, a naturally occurring truncated isoform acts as a tumor suppressor. We previously demonstrated that truncated STAT5...

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Bibliographic Details
Main Author: Aleksandra Shchelkunova, Boris Ermolinsky, Meghan Boyle, Ivan Mendez, Michael Lehker, Karen S. Martirosyan, Alexander V. Kazansky
Format: Article
Language:English
Published: Ivyspring International Publisher 2013-01-01
Series:International Journal of Biological Sciences
Online Access:http://www.biolsci.org/v09p0045.htm