High concentrations of middle ear antimicrobial peptides and proteins and proinflammatory cytokines are associated with detection of middle ear pathogens in children with recurrent acute otitis media.

High concentrations of middle ear antimicrobial peptides and proteins and proinflammatory cytokines are associated with detection of middle ear pathogens in children with recurrent acute otitis media.

Recurrent and chronic otitis media (OM) are often refractory to antibiotics due to bacterial persistence in biofilm within the middle ear. In vitro and in vivo studies have demonstrated that antimicrobial proteins and peptides (AMPs) are bactericidal against otopathogens, indicating potential therap...

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Bibliographic Details
Main Authors: Elke J Seppanen, Ruth B Thornton, Karli J Corscadden, Caitlyn M Granland, Julie Hibbert, Angela Fuery, Selma P Wiertsema, Shyan Vijayasekaran, Harvey L Coates, Peter Jacoby, Andrew Currie, Peter C Richmond, Lea-Ann S Kirkham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0227080

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https://doi.org/10.1371/journal.pone.0227080

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