Native and oxidised lipoproteins negatively regulate the serum amyloid A‐induced NLRP3 inflammasome activation in human macrophages

Native and oxidised lipoproteins negatively regulate the serum amyloid A‐induced NLRP3 inflammasome activation in human macrophages

Abstract Objectives The NLRP3 inflammasome plays a key role in arterial wall inflammation. In this study, we elucidated the role of serum lipoproteins in the regulation of NLRP3 inflammasome activation by serum amyloid A (SAA) and other inflammasome activators. Methods The effect of lipoproteins on...

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Bibliographic Details
Main Authors: Katariina Nurmi, Katri Niemi, Ilona Kareinen, Kristiina Silventoinen, Martina B Lorey, Yan Chen, Vesa‐Petteri Kouri, Jukka Parantainen, Timo Juutilainen, Katariina Öörni, Petri T Kovanen, Dan Nordström, Sampsa Matikainen, Kari K Eklund
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
extracellular vesicle
high‐density lipoprotein
low‐density lipoprotein
NLRP3 inflammasome activation
oxidised lipoprotein
serum amyloid A
Online Access:https://doi.org/10.1002/cti2.1323

Internet

https://doi.org/10.1002/cti2.1323

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