Therapeutic Delivery of rAAV <i>sox9</i> via Polymeric Micelles Counteracts the Effects of Osteoarthritis-Associated Inflammatory Cytokines in Human Articular Chondrocytes

Therapeutic Delivery of rAAV <i>sox9</i> via Polymeric Micelles Counteracts the Effects of Osteoarthritis-Associated Inflammatory Cytokines in Human Articular Chondrocytes

Osteoarthritis (OA) is a prevalent joint disease linked to the irreversible degradation of key extracellular cartilage matrix (ECM) components (proteoglycans, type-II collagen) by proteolytic enzymes due to an impaired tissue homeostasis, with the critical involvement of OA-associated pro-inflammato...

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Bibliographic Details
Main Authors: Jonas Urich, Magali Cucchiarini, Ana Rey-Rico
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Nanomaterials
Subjects:
osteoarthritis
human articular cartilage
rAAV vectors
SOX9
polymeric micelles
pro-inflammatory cytokines
Online Access:https://www.mdpi.com/2079-4991/10/6/1238

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https://www.mdpi.com/2079-4991/10/6/1238

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