Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils

Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration of the nigrostriatal system and motor deficits can be useful tools for Parkinson's disease (PD) research. The preformed fibril (PFF) synucleinopathy model in rodents...

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Bibliographic Details
Main Authors: Joseph R. Patterson, Megan F. Duffy, Christopher J. Kemp, Jacob W. Howe, Timothy J. Collier, Anna C. Stoll, Kathryn M. Miller, Pooja Patel, Nathan Levine, Darren J. Moore, Kelvin C. Luk, Sheila M. Fleming, Nicholas M. Kanaan, Katrina L. Paumier, Omar M.A. El-Agnaf, Caryl E. Sortwell
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Alpha-Synuclein
Preformed fibrils
Synucleinopathy
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301937

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http://www.sciencedirect.com/science/article/pii/S0969996119301937

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