3D Pharmacophore-Based Discovery of Novel K<sub>V</sub>10.1 Inhibitors with Antiproliferative Activity

3D Pharmacophore-Based Discovery of Novel K<sub>V</sub>10.1 Inhibitors with Antiproliferative Activity

(1) Background: The voltage-gated potassium channel K<sub>V</sub>10.1 (Eag1) is considered a near- universal tumour marker and represents a promising new target for the discovery of novel anticancer drugs. (2) Methods: We utilized the ligand-based drug discovery methodology using 3D phar...

Full description

Bibliographic Details
Main Authors: Žan Toplak, Louise Antonia Hendrickx, Špela Gubič, Štefan Možina, Bojana Žegura, Alja Štern, Matjaž Novak, Xiaoyi Shi, Steve Peigneur, Jan Tytgat, Tihomir Tomašič, Luis A. Pardo, Lucija Peterlin Mašič
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
K<sub>V</sub>10.1
ion channels
hERG
pharmacophore modelling
virtual screening
antiproliferative activity
Online Access:https://www.mdpi.com/2072-6694/13/6/1244

Internet

https://www.mdpi.com/2072-6694/13/6/1244

Similar Items