Dichloro-Phenyl-Benzotriazoles: A New Selective Class of Human Respiratory Syncytial Virus Entry Inhibitors

Dichloro-Phenyl-Benzotriazoles: A New Selective Class of Human Respiratory Syncytial Virus Entry Inhibitors

Human Respiratory Syncytial Virus (RSV) is the primary cause of bronchopneumonia in infants and children worldwide. Clinical studies have shown that early treatments of RSV patients with ribavirin improve prognosis, even if the use of this drug is limited due to myelosuppression and toxicity effects...

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Bibliographic Details
Main Authors: Sandra Piras, Giuseppina Sanna, Antonio Carta, Paola Corona, Roberta Ibba, Roberta Loddo, Silvia Madeddu, Paola Caria, Suzana Aulic, Erik Laurini, Maurizio Fermeglia, Sabrina Pricl
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Chemistry
Subjects:
dichloro-phenylbenzotriazoles
RSV strain B1 cp-52
fusion protein
plasmid-based reporter assay
in silico modeling
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00247/full

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https://www.frontiersin.org/article/10.3389/fchem.2019.00247/full

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