Autophagic impairment contributes to systemic inflammation-induced dopaminergic neuron loss in the midbrain.

Autophagic impairment contributes to systemic inflammation-induced dopaminergic neuron loss in the midbrain.

BACKGROUND: Neuroinflammation plays an important role in the pathogenesis of Parkinson's disease (PD), inducing and accelerating dopaminergic (DA) neuron loss. Autophagy, a critical mechanism for clearing misfolded or aggregated proteins such as α-synuclein (α-SYN), may affect DA neuron surviva...

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Main Authors: Hui-Fen Zheng, Ya-Ping Yang, Li-Fang Hu, Mei-Xia Wang, Fen Wang, Li-Dan Cao, Da Li, Cheng-Jie Mao, Kang-Ping Xiong, Jian-Da Wang, Chun-Feng Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3735600?pdf=render

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http://europepmc.org/articles/PMC3735600?pdf=render

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