Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis

Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis

Abstract Background The recent findings of cancer-specific metabolic changes, including increased glucose and glutamine consumption, have provided new therapeutic targets for consideration. Fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients exhibit several tumor cell-like cha...

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Bibliographic Details
Main Authors: Soshi Takahashi, Jun Saegusa, Sho Sendo, Takaichi Okano, Kengo Akashi, Yasuhiro Irino, Akio Morinobu
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Arthritis Research & Therapy
Subjects:
Fibroblasts
Glutaminolysis
Glutamine
Metabolomics
Rheumatoid arthritis
Online Access:http://link.springer.com/article/10.1186/s13075-017-1283-3

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http://link.springer.com/article/10.1186/s13075-017-1283-3

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