Tripeptide-Catalyzed Asymmetric Aldol Reaction Between α-ketoesters and Acetone Under Acidic Cocatalyst-Free Conditions

Here, we report the tripeptide-catalyzed asymmetric aldol reaction between &#945;-ketoesters and acetone under acidic cocatalysts-free conditions. H-Pro-Tle-Gly-OH <b>3g</b>-catalyzed reactions between &#945;-ketoesters and acetone resulted in up to 95% yield and 88% ee. Analysis...

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Bibliographic Details
Main Authors: Kazumasa Kon, Hiromu Takai, Yoshihito Kohari, Miki Murata
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Catalysts
Subjects:
Online Access:https://www.mdpi.com/2073-4344/9/6/514