Activation of Bacterial Histidine Kinases: Insights into the Kinetics of the cis Autophosphorylation Mechanism

Activation of Bacterial Histidine Kinases: Insights into the Kinetics of the cis Autophosphorylation Mechanism

Two-component systems consisting of an input-sensing histidine kinase (HK) and an output-generating response regulator (RR) are one of the key apparatuses utilized by bacteria for adapting to the extracellular milieu. HK autophosphorylation is shown to occur primarily in trans (intermolecular) and m...

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Bibliographic Details
Main Authors: Gaurav D. Sankhe, Narendra M. Dixit, Deepak K. Saini
Format: Article
Language:English
Published: American Society for Microbiology 2018-05-01
Series:mSphere
Subjects:
Mycobacterium tuberculosis
two-component signaling
autophosphorylation
cis autophosphorylation
histidine kinase
mathematical modeling
Online Access:https://doi.org/10.1128/mSphere.00111-18

Internet

https://doi.org/10.1128/mSphere.00111-18

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