HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

Members of the nuclear receptor (NR) superfamily regulate both physiological and pathophysiological processes ranging from development and metabolism to inflammation and cancer. Synthetic small molecules targeting NRs are often deployed as therapeutics to correct aberrant NR signaling or as chemical...

Full description

Bibliographic Details
Main Authors: Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
nuclear receptors
hydrogen-deuterium exchange
ligand activation
Online Access:https://elifesciences.org/articles/47172

Internet

https://elifesciences.org/articles/47172

Similar Items