Genetic and Non-genetic Factors Contributing to the Significant Variation in the Plasma Trough Concentration-to-Dose Ratio of Valproic Acid in Children With Epilepsy

Genetic and Non-genetic Factors Contributing to the Significant Variation in the Plasma Trough Concentration-to-Dose Ratio of Valproic Acid in Children With Epilepsy

Objective: This study was conducted to evaluate the potential genetic and non-genetic factors contributing to plasma trough concentration-to-dose (C0/D) ratio of valproic acid (VPA) in pediatric patients with epilepsy.Study Design: A single-center, retrospective cohort study was performed by collect...

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Bibliographic Details
Main Authors: Ze-Yue Xu, Hong-Li Guo, Ling Li, Min Zhang, Xia Jing, Ze-Jun Xu, Jin-Chun Qiu, Xiao-Peng Lu, Xuan-Sheng Ding, Feng Chen, Jing Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pediatrics
Subjects:
epilepsy
children
valproic acid
C0/D ratio
dosage form
therapeutic drug monitoring
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2020.599044/full

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https://www.frontiersin.org/articles/10.3389/fped.2020.599044/full

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