Impact of Ancestral Differences and Reassessment of the Classification of Previously Reported Pathogenic Variants in Patients With Brugada Syndrome in the Genomic Era: A SADS-TW BrS Registry

Impact of Ancestral Differences and Reassessment of the Classification of Previously Reported Pathogenic Variants in Patients With Brugada Syndrome in the Genomic Era: A SADS-TW BrS Registry

Brugada syndrome (BrS) is a heritable disease that results in sudden cardiac death. In the exome/genomic era, certain reported pathogenic variants in some genetic diseases have been reclassified as benign owing to their high frequency in some ancestries. In the present study, we comprehensively reas...

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Bibliographic Details
Main Authors: Ching-Yu Julius Chen, Tzu-Pin Lu, Lian-Yu Lin, Yen-Bin Liu, Li-Ting Ho, Hui-Chun Huang, Ling-Ping Lai, Juey-Jen Hwang, Shih-Fan Sherri Yeh, Cho-Kai Wu, Jyh-Ming Jimmy Juang, Charles Antzelevitch
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Genetics
Subjects:
Brugada syndrome
sudden cardiac death
inherited cardiac arrhythmia syndrome
allele frequency
pathogenic variants
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00680/full

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https://www.frontiersin.org/article/10.3389/fgene.2018.00680/full

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