Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells
Presenilin-1 (PS1) is an important determinant of the γ-secretase activity necessary for the generation of β-amyloid (Aβ), likely the central pathogenic molecule in Alzheimer's disease. Most presenilin is rapidly degraded, and determinants of the level of the active cleaved form are unknown. We...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2004-12-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520341183 |